Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

Influenza is an acute respiratory infectious disease caused by the influenza virus, affecting people globally and causing significant social and economic losses. Due to the inevitable limitations of vaccines and approved drugs, there is an urgent need to discover new anti-influenza drugs with differ...

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Bibliographic Details
Main Authors: Lingxin Hou, Ying Zhang, Han Ju, Srinivasulu Cherukupalli, Ruifang Jia, Jian Zhang, Bing Huang, Arianna Loregian, Xinyong Liu, Peng Zhan
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Influenza virus
Drug design
Influenza polymerase
Ribonucleoprotein complex
Medicinal-chemistry strategies
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004561

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http://www.sciencedirect.com/science/article/pii/S2211383521004561

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