Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial
Gastroesophageal adenocarcinoma is a disease of older adults that is associated with a very poor prognosis. It is less common and has better outcomes in females. The reason for this is unknown but may relate to signalling via the main oestrogen receptors (ER) α and β. In this study, we sought to inv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/9/2591 |
| _version_ | 1797602826348658688 |
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| author | Mark A. Baxter Lindsay C. Spender Shaun Walsh Susan Bray Gemma Skinner Sharon King Peter S. Hall Matthew J. Seymour Russell D. Petty on behalf of the GO2 Investigators |
| author_facet | Mark A. Baxter Lindsay C. Spender Shaun Walsh Susan Bray Gemma Skinner Sharon King Peter S. Hall Matthew J. Seymour Russell D. Petty on behalf of the GO2 Investigators |
| author_sort | Mark A. Baxter |
| collection | DOAJ |
| description | Gastroesophageal adenocarcinoma is a disease of older adults that is associated with a very poor prognosis. It is less common and has better outcomes in females. The reason for this is unknown but may relate to signalling via the main oestrogen receptors (ER) α and β. In this study, we sought to investigate this using the GO2 clinical trial patient cohort. GO2 recruited older and/or frail patients with advanced gastroesophageal cancer. Immunohistochemistry was performed on tumour samples from 194 patients. The median age of the population was 76 years (range 52–90), and 25.3% were female. Only one (0.5%) tumour sample was positive for ERα, compared to 70.6% for ERβ expression. There was no survival impact according to ERβ expression level. Female sex and younger age were associated with lower ERβ expression. Female sex was also associated with improved overall survival. To our knowledge, this is the largest study worldwide of ER expression in a cohort of patients with advanced gastroesophageal adenocarcinoma. It is also unique, given the age of the population. We have demonstrated that female sex is associated with better survival outcomes with palliative chemotherapy but that this does not appear to be related to ER IHC expression. The differing ER expression according to age supports the concept of a different disease biology with age. |
| first_indexed | 2024-03-11T04:21:54Z |
| format | Article |
| id | doaj.art-26992c28ef134af99b7fa7ec4e479f59 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T04:21:54Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-26992c28ef134af99b7fa7ec4e479f592023-11-17T22:41:51ZengMDPI AGCancers2072-66942023-05-01159259110.3390/cancers15092591Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 TrialMark A. Baxter0Lindsay C. Spender1Shaun Walsh2Susan Bray3Gemma Skinner4Sharon King5Peter S. Hall6Matthew J. Seymour7Russell D. Petty8on behalf of the GO2 InvestigatorsDivision of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 4HR, UKDivision of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 4HR, UKDepartment of Pathology, Ninewells Hospital and Medical School, NHS Tayside, Dundee DD2 1SY, UKDepartment of Pathology, Ninewells Hospital and Medical School, NHS Tayside, Dundee DD2 1SY, UKDepartment of Pathology, Ninewells Hospital and Medical School, NHS Tayside, Dundee DD2 1SY, UKDepartment of Pathology, Ninewells Hospital and Medical School, NHS Tayside, Dundee DD2 1SY, UKCancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Edinburgh EH4 2XR, UKLeeds Institute of Medical Research at St James’, University of Leeds, Woodhouse, Leeds LS2 9JT, UKDivision of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 4HR, UKGastroesophageal adenocarcinoma is a disease of older adults that is associated with a very poor prognosis. It is less common and has better outcomes in females. The reason for this is unknown but may relate to signalling via the main oestrogen receptors (ER) α and β. In this study, we sought to investigate this using the GO2 clinical trial patient cohort. GO2 recruited older and/or frail patients with advanced gastroesophageal cancer. Immunohistochemistry was performed on tumour samples from 194 patients. The median age of the population was 76 years (range 52–90), and 25.3% were female. Only one (0.5%) tumour sample was positive for ERα, compared to 70.6% for ERβ expression. There was no survival impact according to ERβ expression level. Female sex and younger age were associated with lower ERβ expression. Female sex was also associated with improved overall survival. To our knowledge, this is the largest study worldwide of ER expression in a cohort of patients with advanced gastroesophageal adenocarcinoma. It is also unique, given the age of the population. We have demonstrated that female sex is associated with better survival outcomes with palliative chemotherapy but that this does not appear to be related to ER IHC expression. The differing ER expression according to age supports the concept of a different disease biology with age.https://www.mdpi.com/2072-6694/15/9/2591gastroesophageal canceroestrogen receptorolder adultsprognosisbiomarker |
| spellingShingle | Mark A. Baxter Lindsay C. Spender Shaun Walsh Susan Bray Gemma Skinner Sharon King Peter S. Hall Matthew J. Seymour Russell D. Petty on behalf of the GO2 Investigators Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial Cancers gastroesophageal cancer oestrogen receptor older adults prognosis biomarker |
| title | Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial |
| title_full | Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial |
| title_fullStr | Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial |
| title_full_unstemmed | Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial |
| title_short | Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial |
| title_sort | female sex but not oestrogen receptor expression predicts survival in advanced gastroesophageal adenocarcinoma a post hoc analysis of the go2 trial |
| topic | gastroesophageal cancer oestrogen receptor older adults prognosis biomarker |
| url | https://www.mdpi.com/2072-6694/15/9/2591 |
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