Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells

Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells

CD4+ T cells play a critical role in antitumor immunity via recognition of peptide antigens presented on MHC class II (MHC-II). Although some solid cancers can be induced to express MHC-II, the extent to which this enables direct recognition by tumor-specific CD4+ T cells is unclear. We isolated and...

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Bibliographic Details
Main Authors: Spencer E. Brightman, Martin S. Naradikian, Rukman R. Thota, Angelica Becker, Leslie Montero, Milad Bahmanof, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Bjoern Peters, Ezra E.W. Cohen, Aaron M. Miller, Stephen P. Schoenberger
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-01-01
Series:JCI Insight
Subjects:
Immunology
Oncology
Online Access:https://doi.org/10.1172/jci.insight.165570

Internet

https://doi.org/10.1172/jci.insight.165570

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