Structure-Guided Approach to Discover Tuberosin as a Potent Activator of Pyruvate Kinase M2, Targeting Cancer Therapy

Structure-Guided Approach to Discover Tuberosin as a Potent Activator of Pyruvate Kinase M2, Targeting Cancer Therapy

Metabolic reprogramming is a key attribute of cancer progression. An altered expression of pyruvate kinase M2 (PKM2), a phosphotyrosine-binding protein is observed in many human cancers. PKM2 plays a vital role in metabolic reprogramming, transcription and cell cycle progression and thus is delibera...

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Bibliographic Details
Main Authors: Mohd Adnan, Anas Shamsi, Abdelbaset Mohamed Elasbali, Arif Jamal Siddiqui, Mitesh Patel, Nawaf Alshammari, Salem Hussain Alharethi, Hassan H. Alhassan, Fevzi Bardakci, Md. Imtaiyaz Hassan
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
pyruvate kinase M2
phytoconstituents
tuberosin
virtual screening
molecular dynamics simulations
principal component analysis
Online Access:https://www.mdpi.com/1422-0067/23/21/13172

Internet

https://www.mdpi.com/1422-0067/23/21/13172

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