The immunoregulatory role of fish specific type II SOCS via inhibiting metaflammation in the gut-liver axis

The immunoregulatory role of fish specific type II SOCS via inhibiting metaflammation in the gut-liver axis

SOCS8, also known as CISHb, is a fish-specific type II SOCS. Because CISH binds to cytokine receptors and may inhibit STAT5 activation (a substrate of the insulin receptor), SOCS8 may be involved in the control of metaflammation. The socs8−/− zebrafish were created, and both longer trunks and intest...

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Bibliographic Details
Main Authors: Junwei Shan, Guangxin Wang, Heng Li, Xuyang Zhao, Weidong Ye, Lian Su, Qingsong Zhu, Yuhang Liu, Yingyin Cheng, Wanting Zhang, Nan Wu, Xiao-Qin Xia
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2023-04-01
Series:Water Biology and Security
Subjects:
Gut-liver axis
Immunoregulation
Insulin signaling
SOCS8
Zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S2772735122001718

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http://www.sciencedirect.com/science/article/pii/S2772735122001718

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