Lot-to-lot consistency of a hexavalent DTwP-IPV-HB-PRP∼T vaccine and non-inferiority to separate DTwP-HB-PRP∼T and IPV antigen-matching vaccines at 6–8, 10–12, and 14–16 weeks of age co-administered with oral rotavirus vaccine in healthy infants in India: A multi-center, randomized, controlled study

Lot-to-lot consistency of a hexavalent DTwP-IPV-HB-PRP∼T vaccine and non-inferiority to separate DTwP-HB-PRP∼T and IPV antigen-matching vaccines at 6–8, 10–12, and 14–16 weeks of age co-administered with oral rotavirus vaccine in healthy infants in India: A multi-center, randomized, controlled study

Background: Combination vaccines reduce the number of pediatric injections but must be as safe, immunogenic, and effective as each of the individual vaccines given separately. Additionally, consistency in manufacturing lots is essential for WHO prequalification. This study aimed to establish the lot...

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Bibliographic Details
Main Authors: S Mangarule, S Prashanth, A Kawade, MD Ravi, IV Padmavathi, S Palkar, VN Tripathi, R Singh, M Maurya, M Mitra, RS Shetty, RZ Kompithra, SM Dhaded, V Epari, A Moureau, MV Jayanth, K Varghese, S Ravinuthala, D Kukian, BN Patnaik, F Noriega
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Vaccine: X
Subjects:
Co-administration
Combination vaccine
Hexavalent
Lot-to-lot consistency
Immunogenicity
Non-inferiority
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136222000766

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http://www.sciencedirect.com/science/article/pii/S2590136222000766

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