Comparing the Effect of Multiple Histone Deacetylase Inhibitors on SSTR2 Expression and [<sup>111</sup>In]In-DOTATATE Uptake in NET Cells

Comparing the Effect of Multiple Histone Deacetylase Inhibitors on SSTR2 Expression and [<sup>111</sup>In]In-DOTATATE Uptake in NET Cells

The aim of this study was to increase somatostatin type-2 receptor (SSTR2) expression on neuroendocrine tumor (NET) cells using histone deacetylase inhibitors (HDACis), potentially increasing the uptake of SSTR2-targeted radiopharmaceuticals and subsequently improving treatment efficacy of peptide r...

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Bibliographic Details
Main Authors: Maria J. Klomp, Simone U. Dalm, Peter M. van Koetsveld, Fadime Dogan, Marion de Jong, Leo J. Hofland
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
neuroendocrine tumors
peptide receptor radionuclide therapy
somatostatin type-2 receptors
SSTR2
[<sup>111</sup>In]In-DOTATATE
upregulation
Online Access:https://www.mdpi.com/2072-6694/13/19/4905

Internet

https://www.mdpi.com/2072-6694/13/19/4905

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