Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that works under acute transcriptional control by several stimuli, including serum and glucocorticoids. It plays a significant role in the cancer progression and metastasis, as it regulates inflammation, apoptosis, hormo...
Autori principali: | , , , , , , , |
---|---|
Natura: | Articolo |
Lingua: | English |
Pubblicazione: |
MDPI AG
2020-02-01
|
Serie: | Molecules |
Soggetti: | |
Accesso online: | https://www.mdpi.com/1420-3049/25/4/823 |