Histone deacetylase inhibitors attenuated interleukin-1β-induced chondrogenesis inhibition in synovium-derived mesenchymal stem cells of the temporomandibular joint

Histone deacetylase inhibitors attenuated interleukin-1β-induced chondrogenesis inhibition in synovium-derived mesenchymal stem cells of the temporomandibular joint

Aims: In the repair of condylar cartilage injury, synovium-derived mesenchymal stem cells (SMSCs) migrate to an injured site and differentiate into cartilage. This study aimed to confirm that histone deacetylase (HDAC) inhibitors, which alleviate arthritis, can improve chondrogenesis inhibited by IL...

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Bibliographic Details
Main Authors: Wen-ting Liao, Jia-dong Sun, Yun Wang, Yi-qing He, Kai Su, Yun-yang Lu, Guiqing Liao, Yang-peng Sun
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2022-01-01
Series:Bone & Joint Research
Subjects:
histone deacetylase inhibitors
temporomandibular joint
synovium
mesenchymal stem cell
il-1β
synovium-derived mesenchymal stem cells
chondrogenesis
interleukin-1β
il-6
matrix metalloproteinase 13
cartilage
mouse model
arthritis
condylar cartilage
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.111.BJR-2021-0059.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.111.BJR-2021-0059.R1

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