CD25 targeting with the afucosylated human IgG1 antibody RG6292 eliminates regulatory T cells and CD25+ blasts in acute myeloid leukemia

CD25 targeting with the afucosylated human IgG1 antibody RG6292 eliminates regulatory T cells and CD25+ blasts in acute myeloid leukemia

BackgroundAcute Myeloid leukemia is a heterogeneous disease that requires novel targeted treatment options tailored to the patients’ specific microenvironment and blast phenotype.MethodsWe characterized bone marrow and/or blood samples of 37 AML patients and healthy donors by high dimensional flow c...

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Bibliographic Details
Main Authors: Laurène Pousse, Koorosh Korfi, Bruno C. Medeiros, Marco Berrera, Nadine Kumpesa, Jan Eckmann, Idil Karakoc Hutter, Vera Griesser, Vaios Karanikas, Christian Klein, Maria Amann
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia (AML)
leukemic stem cells (LSC)
regulatory T cell (Treg)
CD25
antibody dependent cellular cytotoxicity (ADCC)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1150149/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1150149/full

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