Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice

Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice

The interleukin-17 (IL-17) family, especially IL-17A, plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). This study developed an IL-17A epitope vaccine to treat SLE in NZBWF1 and MRL/lpr mouse models. A plasmid vector encoding a hepatitis B core (HBc)-IL-17A epitope f...

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Bibliographic Details
Main Authors: Hiroshi Koriyama, Yuka Ikeda, Hironori Nakagami, Munehisa Shimamura, Shota Yoshida, Hiromi Rakugi, Ryuichi Morishita
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
il-17a
vaccine
sle
Online Access:https://www.mdpi.com/2076-393X/8/1/83

Internet

https://www.mdpi.com/2076-393X/8/1/83

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