SRPK1/AKT axis promotes oxaliplatin-induced anti-apoptosis via NF-κB activation in colon cancer

SRPK1/AKT axis promotes oxaliplatin-induced anti-apoptosis via NF-κB activation in colon cancer

Abstract Background Colorectal cancer is the third most common diagnosis. Oxaliplatin is used as first-line treatment of colon cancer. However, oxaliplatin resistance greatly reduces its therapeutic effect. SRPK1 involves in pre-mRNA splicing and tumorigenesis. How SRPK1 mediates drug resistance in...

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Bibliographic Details
Main Authors: Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang, Li-Yun Gong
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Translational Medicine
Subjects:
SRPK1
NF-κB activation
Colon cancer
Anti-apoptosis
Oxaliplatin resistance
Online Access:https://doi.org/10.1186/s12967-021-02954-8

Internet

https://doi.org/10.1186/s12967-021-02954-8

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