Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes

Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes

Inwardly rectifying potassium (Kir) 4.1 channels in astrocytes regulate neuronal excitability by mediating spatial potassium buffering. Although dysfunction of astrocytic Kir4.1 channels is implicated in the development of epileptic seizures, the functional mechanisms of Kir4.1 channels in modulatin...

Full description

Bibliographic Details
Main Authors: Masato Kinboshi, Takahiro Mukai, Yuki Nagao, Yusuke Matsuba, Yoshimi Tsuji, Shiho Tanaka, Kentaro Tokudome, Saki Shimizu, Hidefumi Ito, Akio Ikeda, Atsushi Inanobe, Yoshihisa Kurachi, Seiji Inoue, Yukihiro Ohno
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
astrocytes
Kir4.1 channels
BDNF
epilepsy
antidepressants
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00408/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00408/full

Similar Items