In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands

In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands

The kappa opioid receptor (KOR) represents an attractive target for the development of drugs as potential antidepressants, anxiolytics and analgesics. A robust computational approach may guarantee a reduction in costs in the initial stages of drug discovery, novelty and accurate results. In this wor...

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Bibliographic Details
Main Authors: Azzurra Stefanucci, Valeria Iobbi, Alice Della Valle, Giuseppe Scioli, Stefano Pieretti, Paola Minosi, Sako Mirzaie, Ettore Novellino, Adriano Mollica
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
peptides
molecular modelling
k-opioid receptor
antinociceptive effect
binding
Online Access:https://www.mdpi.com/1420-3049/26/16/4767

Internet

https://www.mdpi.com/1420-3049/26/16/4767

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