WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation

WFDC12-overexpressing contributes to the development of atopic dermatitis via accelerating ALOX12/15 metabolism and PAF accumulation

Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczema-like skin lesions, dry skin, severe itching, and recurrent recurrence. The whey acidic protein four-disulfide core domain gene WFDC12 is highly expressed in skin tissue and up-regulated in the skin lesions...

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Main Authors: Guolin Li, Linna Gu, Fulei Zhao, Yawen Hu, Xiaoyan Wang, Fanlian Zeng, Jiadong Yu, Chengcheng Yue, Pei Zhou, Ya Li, Yuting Feng, Jing Hu, Nongyu Huang, Wenling Wu, Kaijun Cui, Wei Li, Jiong Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05686-3

Internet

https://doi.org/10.1038/s41419-023-05686-3

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