In Vitro and In Silico Evaluation of Antiproliferative Activity of New Isoxazolidine Derivatives Targeting EGFR: Design, Synthesis, Cell Cycle Analysis, and Apoptotic Inducers

In Vitro and In Silico Evaluation of Antiproliferative Activity of New Isoxazolidine Derivatives Targeting EGFR: Design, Synthesis, Cell Cycle Analysis, and Apoptotic Inducers

A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for their anticancer activities against three human cancer cell lines such as human breast carcinoma (MCF-7), human lung adenocarcinoma (A-549), and human ovarian carcinoma (SKOV3) by employing MTT assay. The synt...

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Bibliographic Details
Main Authors: Fahad Alminderej, Siwar Ghannay, Mohamed O. Elsamani, Fahad Alhawday, Abuzar E. A. E. Albadri, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Adel Kadri, Kaïss Aouadi
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
molecular dynamics
molecular docking simulation
isoxazolidine
anticancer
EGFR
apoptosis
Online Access:https://www.mdpi.com/1424-8247/16/7/1025

Internet

https://www.mdpi.com/1424-8247/16/7/1025

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