Male breast cancer: No evidence for mosaic BRCA1 promoter methylation involvement

Male breast cancer: No evidence for mosaic BRCA1 promoter methylation involvement

Breast cancers (BC) are rare in men and are often caused by constitutional predisposing factors. In women, mosaic BRCA1 promoter methylations (MBPM) are frequent events, detected in 4–8% of healthy subjects. This constitutional epimutation increases risk of early-onset and triple-negative BC. Howeve...

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Bibliographic Details
Main Authors: Mathias Schwartz, Sabrina Ibadioune, Sophie Vacher, Marie-Charlotte Villy, Olfa Trabelsi-Grati, Jessica Le Gall, Sandrine M. Caputo, Hélène Delhomelle, Mathilde Warcoin, Virginie Moncoutier, Christine Bourneix, Nadia Boutry-Kryza, Antoine De Pauw, Marc-Henri Stern, Bruno Buecher, Emmanuelle Mouret-Fourme, Chrystelle Colas, Dominique Stoppa-Lyonnet, Julien Masliah-Planchon, Lisa Golmard, Ivan Bieche
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Breast
Subjects:
HBOC syndrome
Breast neoplasm
Genetic testing
Homologous recombination
DNA methylation
Epigenomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0960977623007464

Internet

http://www.sciencedirect.com/science/article/pii/S0960977623007464

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