m6A methyltransferase KIAA1429 acts as an oncogenic factor in colorectal cancer by regulating SIRT1 in an m6A-dependent manner

m6A methyltransferase KIAA1429 acts as an oncogenic factor in colorectal cancer by regulating SIRT1 in an m6A-dependent manner

Abstract N6-methyladenosine (m6A) modifications of RNAs are involved in various aspects of colorectal carcinogenesis via regulation of mRNA stability, splicing, and translation. KIAA1429, an m6A methyltransferase, was found deregulated in multiple cancer types. However, its role in colorectal cancer...

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Bibliographic Details
Main Authors: Yuan Zhou, Zhengda Pei, Aizezi Maimaiti, Linyi Zheng, Zhongcheng Zhu, Mengxiang Tian, Zhongyi Zhou, Fengbo Tan, Qian Pei, Yuqiang Li, Wenxue Liu
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00878-w

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https://doi.org/10.1038/s41420-022-00878-w

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