Sildenafil augments fetal weight and placental adiponectin in gestational testosterone-induced glucose intolerant rats

Sildenafil augments fetal weight and placental adiponectin in gestational testosterone-induced glucose intolerant rats

Testosterone induces intra-uterine growth restriction (IUGR) with maternal glucose dysregulation and oxidant release in various tissues. Adiponectin, which modulates the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf2) signaling is expressed in the placenta and affects fetal growth. Si...

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Bibliographic Details
Main Authors: Emmanuel Damilare Areola, Ifeoluwa Jesufemi Adewuyi, Taofeek Olumayowa Usman, God’sgift Tamunoibuomi, Lucy Kemi Arogundade, Barakat Olaoye, Deborah Damilayo Matt-Ojo, Abdulrazaq Olatunji Jeje, Adewumi Oluwafemi Oyabambi, Enoch Abiodun Afolayan, Lawrence Aderemi Olatunji
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Toxicology Reports
Subjects:
Adiponectin
Poor fetal outcome
Androgen
Pregnancy
Placental inefficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750021001207

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http://www.sciencedirect.com/science/article/pii/S2214750021001207

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