An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol [version 1; peer review: 2 approved]

An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol [version 1; peer review: 2 approved]

Background: Soil-transmitted helminths (STH) are targeted for control through mass drug-administration campaigns to prevent morbidity affecting at-risk groups in endemic regions. Although broadly successful, the use of albendazole and mebendazole achieved variable progress, with deficiencies against...

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Bibliographic Details
Main Authors: Inacio Mandomando, Alejandro Krolewiecki, Javier Gandasegui, Wendemagegn Enbiale, Stella Kepha, Lisette van Lieshout, Michel Bengtson, Augusto Messa Junior, Valdemiro Escola, Woyneshet Gelaye, María Cambra-Pellejà, María Martinez-Valladares, Pedro Fleitas, Jaime Algorta, Stephen R. Doyle, Maria Rosa Ballester, Almudena Legarda, Nana Aba Williams, José Muñoz, Helena Martí-Soler, Charles Mwandawiro
Format: Article
Language:English
Published: F1000 Research Ltd 2022-05-01
Series:Gates Open Research
Subjects:
Antihelmintics
STH
Trichuris trichiura
Strongyloides
Hookworm
Albendazole
eng
Online Access:https://gatesopenresearch.org/articles/6-62/v1

Internet

https://gatesopenresearch.org/articles/6-62/v1

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