Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing

Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing

Ageing is associated with increased vulnerability to environmental cold exposure. Previously, we identified the role of the cold-sensitive transient receptor potential (TRP) A1, M8 receptors as vascular cold sensors in mouse skin. We hypothesised that this dynamic cold-sensor system may become dysfu...

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Bibliographic Details
Main Authors: Dibesh Thapa, Joäo de Sousa Valente, Brentton Barrett, Matthew John Smith, Fulye Argunhan, Sheng Y Lee, Sofya Nikitochkina, Xenia Kodji, Susan D Brain
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
ageing
TRPM8
TRPA1
cold response
vascular response
thermoregulation
Online Access:https://elifesciences.org/articles/70153

Internet

https://elifesciences.org/articles/70153

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