Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration

Lysolipids are prominent in subretinal drusenoid deposits, a high-risk phenotype in age-related macular degeneration

IntroductionAge related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases. Extracellular deposits, including drusen and subretinal drusenoid deposits (SDD; also called reticular pseudodrusen), disrupt cone an...

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Bibliographic Details
Main Authors: David M. G. Anderson, Ankita Kotnala, Lukasz G. Migas, N. Heath Patterson, Léonore E. M. Tideman, Dongfeng Cao, Bibek Adhikari, Jeffrey D. Messinger, Thomas Ach, Sara Tortorella, Raf Van de Plas, Christine A. Curcio, Kevin L. Schey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Ophthalmology
Subjects:
age-related macular degeneration
imaging mass spectrometry
subretinal drusenoid deposit
retinal pigment epithelium
lysolipid
interpretable supervised machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fopht.2023.1258734/full

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https://www.frontiersin.org/articles/10.3389/fopht.2023.1258734/full

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