Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro

Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro

Cardiotoxicity is one of the main side effects of doxorubicin (Dox) treatment. Dox could induce oxidative stress, leading to an opening of the mitochondrial permeability transition pore (mPTP) and apoptosis in cardiomyocytes. Previous studies have shown that Cryptotanshinone (Cts) has potential card...

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Bibliographic Details
Main Authors: Xiaoping Wang, Qianbin Sun, Qianqian Jiang, Yanyan Jiang, Yawen Zhang, Jing Cao, Linghui Lu, Chun Li, Peng Wei, Qiyan Wang, Yong Wang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
cardiotoxicity
doxorubicin
cryptotanshinone
oxidative stress
apoptosis
mPTP
Online Access:https://www.mdpi.com/1420-3049/26/5/1460

Internet

https://www.mdpi.com/1420-3049/26/5/1460

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