Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer.

Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer.

BACKGROUND: Human non-small cell lung cancer (NSCLC) patients exhibit a high propensity to develop skeletal metastasis, resulting in excessive osteolytic activity. The RANKL/RANK/OPG system, which plays a pivotal role in bone remodeling by regulating osteoclast formation and activity, is of potentia...

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Bibliographic Details
Main Authors: Xianbo Peng, Wei Guo, Tingting Ren, Zhiyuan Lou, Xinchang Lu, Shuai Zhang, Qunshan Lu, Yifeng Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3596380?pdf=render

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http://europepmc.org/articles/PMC3596380?pdf=render

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