Inhibition of ATP-Sensitive K+ Channels and L-Type Ca2+ Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells

Inhibition of ATP-Sensitive K+ Channels and L-Type Ca2+ Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells

Abstract.: Some class I antiarrhythmic drugs induce a sporadic hypoglycemia by producing insulin secretion via inhibition of ATP-sensitive K+ (KATP) channels of pancreatic β-cells. It remains undetermined whether amiodarone produces insulin secretion by inhibiting KATP channels. In this study, effec...

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Bibliographic Details
Main Authors: Atsushi Nishida, Taichi Takizawa, Akio Matsumoto, Takashi Miki, Susumu Seino, Haruaki Nakaya
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319307236

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http://www.sciencedirect.com/science/article/pii/S1347861319307236

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