Loss of Astrocytic µ Opioid Receptors Exacerbates Aversion Associated with Morphine Withdrawal in Mice: Role of Mitochondrial Respiration

Loss of Astrocytic µ Opioid Receptors Exacerbates Aversion Associated with Morphine Withdrawal in Mice: Role of Mitochondrial Respiration

Astrocytes express mu/µ opioid receptors, but the function of these receptors remains poorly understood. We evaluated the effects of astrocyte-restricted knockout of µ opioid receptors on reward- and aversion-associated behaviors in mice chronically exposed to morphine. Specifically, one of the flox...

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Bibliographic Details
Main Authors: Kateryna Murlanova, Yan Jouroukhin, Ksenia Novototskaya-Vlasova, Shovgi Huseynov, Olga Pletnikova, Michael J. Morales, Yun Guan, Atsushi Kamiya, Dwight E. Bergles, David M. Dietz, Mikhail V. Pletnikov
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
astrocytes
µ opioid receptor
morphine withdrawal
oxidative phosphorylation
reward
Online Access:https://www.mdpi.com/2073-4409/12/10/1412

Internet

https://www.mdpi.com/2073-4409/12/10/1412

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