Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors

Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors

The chimeric antibodies anti-CD20 rituximab (Rtx) and anti-TNFα infliximab (Ifx) induce antidrug antibodies (ADAs) in many patients with inflammatory diseases. Because of the key role of CD4 T lymphocytes in the initiation of antibody responses, we localized the CD4 T cell epitopes of Rtx and Ifx. W...

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Bibliographic Details
Main Authors: Moustafa Hamze, Sylvain Meunier, Anette Karle, Abdelaziz Gdoura, Amélie Goudet, Natacha Szely, Marc Pallardy, Franck Carbonnel, Sebastian Spindeldreher, Xavier Mariette, Corinne Miceli-Richard, Bernard Maillère
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
therapeutic antibodies
immunogenicity
antidrug antibody
CD4 T cell epitopes
healthy donors
infliximab
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00500/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00500/full

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