LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome

Abstract Extracellular vesicles (EVs) have emerged as important vectors of intercellular dialogue. High mobility group box protein 1 (HMGB1) is a typical damage-associated molecular pattern (DAMP) molecule, which is cytotoxic and leads to cell death and tissue injury. Whether EVs are involved in the...

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Bibliographic Details
Main Authors: Guozhen Wang, Siyi Jin, Weichang Huang, Yang Li, Jun Wang, Xuguang Ling, Yun Huang, Ye Hu, Congcong Li, Ying Meng, Xu Li
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00729-0

Internet

https://doi.org/10.1038/s41420-021-00729-0

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