SILENCING THE NUCLEOCYTOPLASMIC O-GLCNAC TRANSFERASE REDUCES PROLIFERATION, ADHESION AND MIGRATION OF CANCER AND FETAL HUMAN COLON CELL LINES

SILENCING THE NUCLEOCYTOPLASMIC O-GLCNAC TRANSFERASE REDUCES PROLIFERATION, ADHESION AND MIGRATION OF CANCER AND FETAL HUMAN COLON CELL LINES

The post-translational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is regulated by a unique couple of enzymes. O-GlcNAc transferase (OGT) transfers the GlcNAc residue from UDP-GlcNAc, the final product of the hexosamine biosynthetic pathway (HBP), whereas O-GlcNAcase (OGA)...

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Main Authors: AGATA eSTEENACKERS, STEPHANIE eOLIVIER-VAN STICHELEN, STEFFI FLORINE BALDINI, VANESSA eDEHENNAUT-LEFEBVRE, ROBERT-ALAIN eTOILLON, XUEFEN eLE BOURHIS, IKRAM BELKOURA EL YAZIDI, TONY eLEFEBVRE
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Endocrinology
Subjects:
colorectal cancer
siRNA
O‐GlcNAcylation
O‐linked N‐acetylglucosamine (O‐GlcNAc) transferase (OGT)
colon cell lines
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00046/full

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http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00046/full

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