A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity

Neuroinflammation and hyperexcitability have been implicated in the pathogenesis of neurodegenerative disease, and new models are required to investigate the cellular crosstalk involved in these processes. We developed an approach to generate a quantitative and reproducible triculture system that is...

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Bibliographic Details
Main Authors: Leela Phadke, Dawn H. W. Lau, Nozie D. Aghaizu, Shania Ibarra, Carmen M. Navarron, Lucy Granat, Lorenza Magno, Paul Whiting, Sarah Jolly
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
drug discovery
microglia
astrocytes
neuroinflammation
hyperexcitability
triculture
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1056067/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.1056067/full

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