Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues

Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues

Several new thiazole derivatives linked pyrazole and/or pyridine rings were synthesized based on the versatile precursor 2-(5-acetyl-4-methyl-3-phenylthiazol-2(3H)-ylidene)acetonitrile (1). The synthesized derivatives were optimized using DFT approach in order to inspect the configurations and energ...

Full description

Bibliographic Details
Main Authors: Abrar Bayazeed, Rua B. Alnoman, Kahdr Alatawi, Omar M. Alatawi, Alaa M. Alqahtani, Mariam Mojally, Noof A. Alenazi, Nashwa M. El-Metwaly
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Saudi Chemical Society
Subjects:
Thiazole derivatives
DFT optimization
Anticancer activity
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610323001588

Internet

http://www.sciencedirect.com/science/article/pii/S1319610323001588

Similar Items