Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells

Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells

Rationale: SARS-CoV-2 gains entrance to airway epithelial cells (AECs) through binding of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. However, ACE2 also converts angiotensin II into angiotensin-(1-7) and counterbalances the renin-angiotensin-aldosterone...

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Bibliographic Details
Main Authors: Oghenemega Okoloko, Elizabeth R. Vanderwall, Lucille M. Rich, Maria P. White, Stephen R. Reeves, Whitney E. Harrington, Kaitlyn A. Barrow, Jason S. Debley
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
airway
epithelium
SARS—CoV—2
ACE2
angiotensin-converting eitzyme inhibitors
angiotensin II (A II) receptor antagonists
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.765951/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.765951/full

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