Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling

Abstract The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain incompletely understood. The ABCC transporters core consists of two nucleotide binding domains (NBD1,2) and transmembrane domains (TM...

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Main Authors: Naoto Soya, Haijin Xu, Ariel Roldan, Zhengrong Yang, Haoxin Ye, Fan Jiang, Aiswarya Premchandar, Guido Veit, Susan P. C. Cole, John Kappes, Tamás Hegedüs, Gergely L. Lukacs
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42586-8

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https://doi.org/10.1038/s41467-023-42586-8

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