Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy

Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy

To enhance human prostate-specific membrane antigen (hPSMA)-specific chimeric antigen receptor (CAR) T cell therapy in a hPSMA+ MyC-CaP tumor model, we studied and imaged the effect of lactate dehydrogenase A (LDH-A) depletion on the tumor microenvironment (TME) and tumor progression. Effective LDH-...

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Bibliographic Details
Main Authors: Mayuresh M. Mane, Ivan J. Cohen, Ellen Ackerstaff, Khalid Shalaby, Jenny N. Ijoma, Myat Ko, Masatomo Maeda, Avi S. Albeg, Kiranmayi Vemuri, Jaya Satagopan, Anna Moroz, Juan Zurita, Larissa Shenker, Masahiro Shindo, Tanner Nickles, Ekaterina Nikolov, Maxim A. Moroz, Jason A. Koutcher, Inna Serganova, Vladimir Ponomarev, Ronald G. Blasberg
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
lactate dehydrogenase A
LDH-A
lactate
human prostate-specific membrane antigen
hPSMA
bioluminescence imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520301108

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http://www.sciencedirect.com/science/article/pii/S2372770520301108

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