GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models

GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models

Background: Previous data on glycogen synthase kinase 3 (GSK-3) inhibition in cancer models support a cytotoxic effect with selectivity for tumor cells compared to normal tissue but the effect of these inhibitors in glioma has not been widely studied. Here, we investigate their potential as cytotoxi...

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Bibliographic Details
Main Authors: Anke Brüning-Richardson, Gary C. Shaw, Daniel Tams, Tim Brend, Hitesh Sanganee, Simon T. Barry, Gregory Hamm, Richard J. A. Goodwin, John G. Swales, Henry King, Lynette Steele, Ruth Morton, Anastasia Widyadari, Thomas A. Ward, Filomena Esteves, Marjorie Boissinot, Georgia Mavria, Alastair Droop, Sean E. Lawler, Susan C. Short
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
glioblastoma
GSK-3
centrosome
radiation
cytotoxicity
Online Access:https://www.mdpi.com/2072-6694/13/23/5939

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https://www.mdpi.com/2072-6694/13/23/5939

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