Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma

Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma

BRAF and MEK inhibitors significantly prolong progression-free survival in patients with BRAF mutant melanoma. However, most patients quickly develop drug resistance. The mechanism of drug resistance is complicated and remains to be further explored. Here, we found that inhibition of the MAPK pathwa...

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Bibliographic Details
Main Authors: Kun Zhao, Yanrong Lu, Younan Chen, Jingqiu Cheng, Wengeng Zhang
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
BRAF
MAPK
JAK2
STAT3
melanoma
drug resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300838

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http://www.sciencedirect.com/science/article/pii/S2372770520300838

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