Polyglutamine Repeat Length-Dependent Proteolysis of Huntingtin

Polyglutamine Repeat Length-Dependent Proteolysis of Huntingtin

Amino-terminal fragments of huntingtin, which contain the expanded polyglutamine repeat, have been proposed to contribute to the pathology of Huntington's disease (HD). Data supporting this claim have been generated from patients with HD in which truncated amino-terminal fragments forming intra...

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Bibliographic Details
Main Authors: Banghua Sun, Wei Fan, Aldona Balciunas, Jillian K. Cooper, Gal Bitan, Shirley Steavenson, Paul E. Denis, Yunjen Young, Beverly Adler, Larry Daugherty, Raffi Manoukian, Gary Elliott, Wenyan Shen, Jane Talvenheimo, David B. Teplow, Mitsuru Haniu, Raj Haldankar, Jette Wypych, Christopher A. Ross, Martin Citron, William G. Richards
Format: Article
Language:English
Published: Elsevier 2002-10-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905395

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http://www.sciencedirect.com/science/article/pii/S0969996102905395

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