GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

G protein-coupled receptor (GPCR) kinase 2 (GRK2), which phosphorylates agonist-occupied GPCRs to promote their desensitization, has been investigated as an attractive therapeutic target for cardiovascular and metabolic diseases. Several GRK2-targeted inhibition strategies have been reported includi...

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Bibliographic Details
Main Authors: Monica Thapaliya, Aetas Amponnawarat, John J. G. Tesmer, Hydar Ali
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
GRK2
paroxetine
mast cells
MRGPRX2
FcϵRI
anaphylaxis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032497/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032497/full

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