Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

Abstract Enlarged early endosomes have been visualized in Alzheimer’s disease (AD) and Down syndrome (DS) using conventional confocal microscopy at a resolution corresponding to endosomal size (hundreds of nm). In order to overtake the diffraction limit, we used super-resolution structured illuminat...

Full description

Bibliographic Details
Main Authors: Alexandra Botté, Jeanne Lainé, Laura Xicota, Xavier Heiligenstein, Gaëlle Fontaine, Amal Kasri, Isabelle Rivals, Pollyanna Goh, Orestis Faklaris, Jack-Christophe Cossec, Etienne Morel, Anne-Sophie Rebillat, Dean Nizetic, Graça Raposo, Marie-Claude Potier
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Acta Neuropathologica Communications
Subjects:
Down syndrome
Alzheimer’s disease
Early endosomes
Endocytosis
Electron microscopy
Super-resolution microscopy
Online Access:http://link.springer.com/article/10.1186/s40478-020-00956-z

Internet

http://link.springer.com/article/10.1186/s40478-020-00956-z

Similar Items