Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice

Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice

We have developed DNA aptamers that can inhibit the toxic effects of advanced glycation end products (AGE-Apts). We herein evaluated the effects of AGE-Apts on muscle mass and strength in senescence-accelerated mouse prone 8 (SAMP8) mice. Eight-month-old male SAMP8 mice received subcutaneous infusio...

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Bibliographic Details
Main Authors: Yusaku Mori, Makoto Ohara, Michishige Terasaki, Naoya Osaka, Hironori Yashima, Tomomi Saito, Yurie Otoyama-Kataoka, Takemasa Omachi, Yuichiro Higashimoto, Takanori Matsui, Tomoyasu Fukui, Sho-ichi Yamagishi
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Biomedicines
Subjects:
AGEs
DNA aptamer
MuRF1
muscle atrophy
oxidative stress
sarcopenia
Online Access:https://www.mdpi.com/2227-9059/11/12/3112

Internet

https://www.mdpi.com/2227-9059/11/12/3112

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