Structural Characteristics of PON1 with Leu55Met and Gln192Arg Variants Influencing Oxidative-Stress-Related Diseases: An Integrated Molecular Modeling and Dynamics Study

Structural Characteristics of PON1 with Leu55Met and Gln192Arg Variants Influencing Oxidative-Stress-Related Diseases: An Integrated Molecular Modeling and Dynamics Study

<i>Background and Objectives</i>: PON1 is a multi-functional antioxidant protein that hydrolyzes a variety of endogenous and exogenous substrates in the human system. Growing evidence suggests that the Leu55Met and Gln192Arg substitutions alter PON1 activity and are linked with a variety...

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Bibliographic Details
Main Authors: Sudhan M., Janakiraman V., Sheikh F. Ahmad, Sabry M. Attia, Talha Bin Emran, Rajesh B. Patil, Shiek S. S. J. Ahmed
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Medicina
Subjects:
paraoxonase
variant
oxidative stress
molecular docking
structural modeling
lactones
Online Access:https://www.mdpi.com/1648-9144/59/12/2060

Internet

https://www.mdpi.com/1648-9144/59/12/2060

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