Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP

Summary: Salmonella Typhimurium drives uptake into non-phagocytic host cells by injecting effector proteins that reorganize the actin cytoskeleton. The host actin regulator N-WASP has been implicated in bacterial entry, but its precise role is not clear. We demonstrate that Cdc42-dependent N-WASP ac...

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Bibliographic Details
Main Authors: Anthony Davidson, Peter J. Hume, Nicholas P. Greene, Vassilis Koronakis
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007204