Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy
Despite its prominent therapeutic efficacy, chemotherapy has raised serious concerns due to the severe adverse effects and multidrug resistance evoked, which propels the search for safe and green therapeutic agents. BAMLET (bovine α-lactalbumin made lethal against tumor cell) is a well-known protein...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422000709 |
| _version_ | 1818172673584267264 |
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| author | Wei Pei Ling Cai Xing Gong Li Zhang Jiarong Zhang Ping Zhu Huijun Jiang Chao Wang Shoulin Wang Jin Chen |
| author_facet | Wei Pei Ling Cai Xing Gong Li Zhang Jiarong Zhang Ping Zhu Huijun Jiang Chao Wang Shoulin Wang Jin Chen |
| author_sort | Wei Pei |
| collection | DOAJ |
| description | Despite its prominent therapeutic efficacy, chemotherapy has raised serious concerns due to the severe adverse effects and multidrug resistance evoked, which propels the search for safe and green therapeutic agents. BAMLET (bovine α-lactalbumin made lethal against tumor cell) is a well-known protein-based anticancer agent of selective tumoricidal activity. Here, we prepared oleic acid-modified mesoporous silica nanoparticles (OA-MSNs) conjugated with bovine α-lactalbumin, a lipoprotein complex resembling BAMLET formed on the surface of MSNs (MSN-BAMLET) to load the anticancer drug of docetaxel (DTX). Compared to that of OA-MSNs/DTX, the obtained MSN-BAMLET/DTX with a sustained and pH-responsive drug release behaviors exhibited good biocompatibility and enhanced cytotoxic effect against cancer cells. Moreover, the presence of lipoprotein complex in MSN-BAMLET contributed to the improved dispersion of the composite in solution and the inhibitory effect on the migration of cancer cells. Furthermore, the adsorption profiles of protein corona on the obtained nanoparticles were analyzed. It was found that the marked low amount and abundance of plasma proteins were adsorbed on the α-lactalbumin coated siliceous composite demonstrated its long circulation property. Finally, in vivo study showed that MSN-BAMLET/DTX contributed to the effective cancer ablation and the prolonged survival. Therefore, the constructed MSN-BAMLET of the mesoregular structure and peculiar tumoricidal effect provides a manipulable nanoplatform as drug nanocarrier for therapeutic applications. |
| first_indexed | 2024-12-11T19:16:21Z |
| format | Article |
| id | doaj.art-2705f1b2d7ce44a1bf453ef959419c23 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-12-11T19:16:21Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-2705f1b2d7ce44a1bf453ef959419c232022-12-22T00:53:38ZengElsevierMaterials Today Bio2590-00642022-06-0115100272Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacyWei Pei0Ling Cai1Xing Gong2Li Zhang3Jiarong Zhang4Ping Zhu5Huijun Jiang6Chao Wang7Shoulin Wang8Jin Chen9Center for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, ChinaSchool of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, ChinaCenter for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, ChinaCenter for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, ChinaCenter for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, ChinaCenter for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, ChinaSchool of Pharmacy, Nanjing Medical University, 211166, Nanjing, ChinaCenter for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, ChinaCenter for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 211166, Nanjing, China; Corresponding author. Center for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, China.Center for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, China; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, 211166, Nanjing, China; Jiangsu Province Engineering Research Center of Antibody Drug, Key Laboratory of Antibody Technique of National Health Commission, Nanjing Medical University, Nanjing, 211166, China; Corresponding author. Center for Global Health, School of Public Health, Nanjing Medical University, 211166, Nanjing, China.Despite its prominent therapeutic efficacy, chemotherapy has raised serious concerns due to the severe adverse effects and multidrug resistance evoked, which propels the search for safe and green therapeutic agents. BAMLET (bovine α-lactalbumin made lethal against tumor cell) is a well-known protein-based anticancer agent of selective tumoricidal activity. Here, we prepared oleic acid-modified mesoporous silica nanoparticles (OA-MSNs) conjugated with bovine α-lactalbumin, a lipoprotein complex resembling BAMLET formed on the surface of MSNs (MSN-BAMLET) to load the anticancer drug of docetaxel (DTX). Compared to that of OA-MSNs/DTX, the obtained MSN-BAMLET/DTX with a sustained and pH-responsive drug release behaviors exhibited good biocompatibility and enhanced cytotoxic effect against cancer cells. Moreover, the presence of lipoprotein complex in MSN-BAMLET contributed to the improved dispersion of the composite in solution and the inhibitory effect on the migration of cancer cells. Furthermore, the adsorption profiles of protein corona on the obtained nanoparticles were analyzed. It was found that the marked low amount and abundance of plasma proteins were adsorbed on the α-lactalbumin coated siliceous composite demonstrated its long circulation property. Finally, in vivo study showed that MSN-BAMLET/DTX contributed to the effective cancer ablation and the prolonged survival. Therefore, the constructed MSN-BAMLET of the mesoregular structure and peculiar tumoricidal effect provides a manipulable nanoplatform as drug nanocarrier for therapeutic applications.http://www.sciencedirect.com/science/article/pii/S2590006422000709Drug deliveryMesoporous silica nanoparticleBAMLETα-lactalbuminProtein corona |
| spellingShingle | Wei Pei Ling Cai Xing Gong Li Zhang Jiarong Zhang Ping Zhu Huijun Jiang Chao Wang Shoulin Wang Jin Chen Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy Materials Today Bio Drug delivery Mesoporous silica nanoparticle BAMLET α-lactalbumin Protein corona |
| title | Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy |
| title_full | Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy |
| title_fullStr | Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy |
| title_full_unstemmed | Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy |
| title_short | Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy |
| title_sort | drug loaded oleic acid grafted mesoporous silica nanoparticles conjugated with α lactalbumin resembling bamlet like anticancer agent with improved biocompatibility and therapeutic efficacy |
| topic | Drug delivery Mesoporous silica nanoparticle BAMLET α-lactalbumin Protein corona |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422000709 |
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