MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway

MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway

Abstract Background The development of drug resistance in oral squamous cell carcinoma (OSCC) that frequently leads to recurrence and metastasis after initial treatment remains an unresolved challenge. Presence of cancer stem cells (CSCs) has been increasingly reported to be a critical contributing...

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Bibliographic Details
Main Authors: Te-Hsuan Jang, Wei-Chieh Huang, Shiao-Lin Tung, Sheng-Chieh Lin, Po-Ming Chen, Chun-Yu Cho, Ya-Yu Yang, Tzu-Chen Yen, Guo-Hsuen Lo, Shuang-En Chuang, Lu-Hai Wang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Biomedical Science
Subjects:
Keratin 17
miR-485-5p
Integrin β4
β-catenin
Dasatinib
Cancer stemness
Online Access:https://doi.org/10.1186/s12929-022-00824-z

Internet

https://doi.org/10.1186/s12929-022-00824-z

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