Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in <i>Streptomyces malaysiensis</i> F913

Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in <i>Streptomyces malaysiensis</i> F913

Nigericin is a polyether antibiotic with potent antibacterial, antifungal, antimalarial and anticancer activity. NigR, the only regulator in the nigericin biosynthetic gene cluster in <i>Streptomyces malaysiensis</i> F913, was identified as a SARP family regulator. Disruption of <i>...

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Bibliographic Details
Main Authors: Junhong Wei, Mengting Ma, Senwen Guo, Yaobo Xu, Jie Xie, Guoqing Pan, Zeyang Zhou
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antibiotics
Subjects:
nigericin
<i>Streptomyces malaysiensis</i>
NigR
pathway-specific regulator
Online Access:https://www.mdpi.com/2079-6382/11/7/938

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