Interferon-γ/Interleukin-27 Axis Induces Programmed Death Ligand 1 Expression in Monocyte-Derived Dendritic Cells and Restores Immune Tolerance in Central Nervous System Autoimmunity

Interferon-γ/Interleukin-27 Axis Induces Programmed Death Ligand 1 Expression in Monocyte-Derived Dendritic Cells and Restores Immune Tolerance in Central Nervous System Autoimmunity

Antigen (Ag)-specific tolerance induction by intravenous (i. v.) injection of high-dose auto-Ags has been explored for therapy of autoimmune diseases, including multiple sclerosis (MS). It is thought that the advantage of such Ag-specific therapy over non-specific immunomodulatory treatments would b...

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Bibliographic Details
Main Authors: Giacomo Casella, Javad Rasouli, Rodolfo Thome, Hélène C. Descamps, Asrita Vattikonda, Larissa Ishikawa, Alexandra Boehm, Daniel Hwang, Weifeng Zhang, Dan Xiao, Jeongho Park, Guang-Xian Zhang, Jorge I. Alvarez, Abdolmohamad Rostami, Bogoljub Ciric
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
peripheral tolerance
monocytes
experimental autoimmune encephalitis
PD-L1
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.576752/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.576752/full

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