Modelling the Human Blood–Brain Barrier in Huntington Disease

Modelling the Human Blood–Brain Barrier in Huntington Disease

While blood–brain barrier (BBB) dysfunction has been described in neurological disorders, including Huntington’s disease (HD), it is not known if endothelial cells themselves are functionally compromised when promoting BBB dysfunction. Furthermore, the underlying mechanisms of BBB dysfunction remain...

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Bibliographic Details
Main Authors: Domenico Vignone, Odalys Gonzalez Paz, Ivan Fini, Antonella Cellucci, Giulio Auciello, Maria Rosaria Battista, Isabelle Gloaguen, Silvia Fortuni, Cristina Cariulo, Vinod Khetarpal, Celia Dominguez, Ignacio Muñoz-Sanjuán, Annalise Di Marco
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain barrier
transport
induced pluripotent stem cells
brain endothelial cells
in vitro models
Huntington’s disease
Online Access:https://www.mdpi.com/1422-0067/23/14/7813

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https://www.mdpi.com/1422-0067/23/14/7813

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