Caffeic Acid-PLGA Conjugate to Design Protein Drug Delivery Systems Stable to Irradiation

Caffeic Acid-PLGA Conjugate to Design Protein Drug Delivery Systems Stable to Irradiation

This work reports the feasibility of caffeic acid grafted PLGA (g-CA-PLGA) to design biodegradable sterile microspheres for the delivery of proteins. Ovalbumin (OVA) was selected as model compound because of its sensitiveness of γ-radiation. The adopted grafting procedure allowed us to obtain a mat...

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Bibliographic Details
Main Authors: Francesca Selmin, Francesco Puoci, Ortensia I. Parisi, Silvia Franzé, Umberto M. Musazzi, Francesco Cilurzo
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Journal of Functional Biomaterials
Subjects:
anti-oxidant
microencapsulation
drug release
caffeic acid
grafting
γ-irradiation
microspheres
ovalbumin
poly(lactide-co-glycolide)
sterilization
Online Access:http://www.mdpi.com/2079-4983/6/1/1

Internet

http://www.mdpi.com/2079-4983/6/1/1

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