Overcoming Breast Cancer Drug Resistance: A Novel Approach Using siRNA-Mediated P-glycoprotein Downregulation to Enhance Vinorelbine Efficacy

Overcoming Breast Cancer Drug Resistance: A Novel Approach Using siRNA-Mediated P-glycoprotein Downregulation to Enhance Vinorelbine Efficacy

Purpose: Cancer, the second leading cause of mortality worldwide, represents a global health challenge, primarily due to drug resistance. Vinorelbine is a chemotherapeutic agent that disrupts cancer cell growth by targeting microtubules and inducing apoptosis. However, drug resistance remains a form...

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Bibliographic Details
Main Authors: Zahra Abbasfard, Abbas Behzad-Behbahani, Banafshe Rastegari, Sirous Naeimi, Mehdi Moghanibashi, Fatemeh Safari
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-07-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
drug resistance
gene expression
mcf-7 cells
multiple
small interfering
vinorelbine
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-14-445.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-14-445.pdf

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