RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner

RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A‐YTHDF2‐dependent manner

Abstract Background N6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) is a well‐described m6A demethylase in previous enzyme assays, we aimed to investigate the role of m6A methylation alteration conferred...

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Bibliographic Details
Main Authors: Dingcheng Shen, Jinxin Lin, Yumo Xie, Zhuokai Zhuang, Gaopo Xu, Shaoyong Peng, Guannan Tang, Liangliang Bai, Mingxuan Zhu, Yu Zhang, Ziying Huang, Puning Wang, Xiaoxia Liu, Meijin Huang, Yanxin Luo, Xiaolin Wang, Huichuan Yu
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Clinical and Translational Medicine
Subjects:
ALKBH5
colorectal cancer (CRC)
N6‐methyladenosine (m6A)
RAB5A
Online Access:https://doi.org/10.1002/ctm2.1279

Internet

https://doi.org/10.1002/ctm2.1279

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